Due to the variety of treatment options, dentine hypersensitivity (DH) is a painful disease and a clinical challenge. As a potential solution, high-intensity lasers have been researched. This clinical trial was designed to examine the effects of Er:YAG and Er,Cr:YSGG lasers on DH. It was randomized, controlled, and double-blind. The 28 participants in the study group all satisfied the requirements for inclusion. Sensitivity was measured using a visual analogue scale before therapy as a baseline, immediately before and after treatment, as well as one week and one month following treatment.